Hyphenated NMR Methods in Natural Products Research, Part 1: Direct Hyphenation
نویسندگان
چکیده
منابع مشابه
HPLC-SPE-NMR: a productivity tool in natural products research
Natural products provide excellent potential leads for drug development because of their chemical diversity and biological functionality. However, the productivity of discovery of new, pharmacologically active natural products has traditionally been low due to inherent difficulties and costs associated with extract dereplication, i.e., isolation, purification and structure elucidation of indivi...
متن کاملHPLC-SPE-NMR: a productivity tool in natural products research
Natural products provide excellent potential leads for drug development because of their chemical diversity and biological functionality. However, the productivity of discovery of new, pharmacologically active natural products has traditionally been low due to inherent difficulties and costs associated with extract dereplication, i.e., isolation, purification and structure elucidation of indivi...
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The HPLC-SPE-NMR technique was used for the analysis of a root-bark extract of Croton membranaceus. The components of the extract were separated on an analytical-size reversed-phase HPLC column, the chromatographic peaks were trapped on SPE (solid-phase extraction) cartridges after post-column dilution of the eluate with water and the compounds were eluted from the cartridges with acetonitrile-...
متن کاملAntimycobacterial susceptibility testing methods for natural products research
The emergence of multidrug-resistant strains of Mycobacterium tuberculosis underscores the need of continuous developments on new and efficient methods to determine the susceptibility of isolates of M. tuberculosis in the search for novel antimicrobial agents. Natural products constitute an important source of new drugs, but design and implementation of antimycobacterial susceptibility testing ...
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ژورنال
عنوان ژورنال: Planta Medica
سال: 2005
ISSN: 0032-0943,1439-0221
DOI: 10.1055/s-2005-871298